Results: The chemical structure of minodronic acid monohydrate was confirmed by 1H-NMR, ESI-MS and Single crystal diffraction. This compound had a purity of over 99.8% as determined by HPLC.
Minodronic acid. 180064-38-4. Minodronate (1-Hydroxy-2-(imidazo(1,2-a)pyridin-3-yl)ethane-1,1-diyl)diphosphonic acid. Recalbon.
Based on the relevant literature and data, this paper designed the synthesis route of minodronic acid, and carried out the research. The optimized route is: 2, 2-dimethoxyacetaldehyde and triethyl phosphonoacetate reaction, synthesis 4, 4-dimethoxy-2-butenoic acid ethyl ester, after cyclization, hydrolysis, and phosphorus tribromide reaction, hydrolysis to prepare minodronic acid.Minophosphonic Acid Introduction. Osteoporosis (OP) is a systemic bone disease caused by a variety of causes. It is a systemic bone disease characterized by decreased bone strength and increased risk of fracture. It is prone to fracture due to increased fragility of the bone.Safe and Efficient One-pot Synthesis of Nitro-containing Unsymmetrical Diaryl Ureas with Triphosgene.
Minodronic acid is a third-generation bisphosphonate drug. It is approved for use in Japan for the treatment of osteoporosis. Its mechanism of action involves inhibition of farnesyl pyrophosphate synthase activity. References.Read More
Synthesis and Development of Flurbiprofen Axetil,Minodronic Acid Intermediates and Pharmaceutical Intermediates Author: TianJian Tutor: GuoZuo School: Shanxi University Course: Medicinal Chemistry Keywords: Flurbiprofen Axetil Minodronic acid intermediates Pharmaceutical intermediates CLC: TQ463 Type: Master's thesis Year: 2012 Downloads: 135.Read More
The bone-binding characteristics of minodronic acid and morphological changes in rabbit osteoclasts were analyzed in vitro. In an osteoclast culture with 1 uM minodronic acid, 65% of minodronic acid was bound to bone, and C-terminal cross-linking telopeptide release was inhibited by 96%.Read More
Medronic acid ( conjugate base, medronate ), also known as methylene diphosphonate, is the smallest bisphosphonate. Its complex with radioactive technetium, 99m Tc medronic acid, is used in nuclear medicine to detect bone abnormalities, including metastases.Read More
Minodronic Acid Scheme. Rec.INN. CAS registry number (Chemical Abstracts Service) 0127657-42-5. Chemical Formula. C9-H12-N2-O7-P2. Molecular Weight. 322. Therapeutic Category.Read More
Minodronic acid is a third-generation bisphosphonate approved in Japan for the oral treatment of osteoporosis. Minodronic acid increases the bone mineral density and strength by inhibiting osteoclastic bone resorption. Nitrogen-containing bisphosphonates, such as minodronic acid, induce osteoclast apoptosis by inhibiting farnesyl pyrophosphate.Read More
Minodronic Acid Monohydrate (also known as Bonoteo, YM-529, and YH-529) is a nitrogen-containing bisphosphonate that has a greater inhibitory effect on bone resorption. Mindodronic Acid is used for the treatment of osteoporosis.Read More
Alendronic acid, sold under the brand name Fosamax among others, is a bisphosphonate medication used to treat osteoporosis and Paget's disease of bone. It is taken by mouth. Use is often recommended together with vitamin D, calcium supplementation, and lifestyle changes.Read More
If you experience drowsiness, dizziness, hypotension or a headache as side-effects when using Minodronic Acid medicine then it may not be safe to drive a vehicle or operate heavy machinery.One should not drive a vehicle if using the medicine makes you drowsy, dizzy or lowers your blood-pressure extensively. Pharmacists also advise patients not to drink alcohol with medicines as alcohol.Read More